2 years ago

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Molecular examination in the TGFB signaling pathway failed to demonstrate a statistically significant big difference in phosphorylation of SMADs 2 or three amongst WT and Clic4 null mice following injury, and immunolocalization of CLIC4 in injured read more...

2 years ago

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Summary of AKI experiments The acute kidney injury experiments yielded two salient effects Clic4 null mice are additional susceptible to folic acid induced acute kidney injury, and the absence of CLIC4 has no obvious effect on recovery from acute read more...

2 years ago

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The P SMAD/T SMAD ratio improved considerably by 48 hrs after injury for SMAD2 and SMAD3 in both WT and Clic4 null mice. There is a trend to decrease P SMAD2/ T SMAD2 ratio from the CLIC4 null mice in contrast for the WT mice, but this trend isn&# read more...

2 years ago

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0174 0. 0024 and ?0. 0121 0. 0028 to the WT and Clic4 null, respectively, with the distinction not ap proaching significance with the 95% confidence level. As a result the degree of scarring as reflected in persistent reduction of renal mass for a read more...