2 years ago

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Alcohol-induced GSH depletions from the mitochondria as well as the ER have been demonstrated in hepatocytes [49, 50]. In previous research with a rat model, we demonstrated that chronic ethanol ingestion decreased the cellular GSH pool of ATII ce read more...

2 years ago

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Alcohol metabolic process also promotes the generation of alcohol-derived radicals, this kind of as 1-hydroxyethyl radical [35�C37]. Additionally, in lung tissue and AMs, alcohol also upregulates the expression and actions of NADPH oxidase isofo read more...

2 years ago

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Recent proof showed that a historical past of alcohol abuse is surely an independent risk factor that increases the odds of any at-risk person producing ARDS (Figure 1). The very first study which identified the result of alcohol abuse on ARDS unc read more...

2 years ago

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In alveolar type II (ATII) cells, there was a 60% reduce in GSH and ~40mV oxidation in GSH/GSSG in cells derived from ethanol-fed rats [25]. This ethanol-induced oxidation was also reflected in organelles in which there read more...

2 years ago

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..GSH has the ability to scavenge the two reactive oxygen species (ROS) and reactive nitrogen species (RNS). On oxidation, two hydrogens are donated to form the GSH disulfide (GSSG). Glutathione read more...

2 years ago

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From the alveolar room, AMs phagocytose microbes and orchestrate the immune response, but alcohol abuse suppresses immune responses, worldwide distributors read more...

2 years ago

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Alcohol-induced GSH depletions in the mitochondria along with the ER have already been demonstrated in hepatocytes [49, 50]. In earlier studies by using a rat model, we demonstrated that persistent ethanol ingestion decreased the cellular GSH pool read more...