In summary, a PyGC provides fast screening of various saha hdac types and catalysts, in either the in situ or ex situ configuration. However, which of these configurations more closely resembles the operation of realistic, laboratory-scale reactors has not been determined yet. Limited information on the comparison between the microscale PyGC system and the bench-scale reactors is available in the literature. The primary objective of this study is to directly compare in situ and ex situ CFP in a PyGC system. A wide range of C/B ratios are used for both configurations to provide insight with regards to primary and secondary product formation and operational dynamics in each configuration. The in situ and ex situ PyGC experimental results are compared with the results obtained from a bench-scale, spouted-bed reactor operated under identical conditions. The objective of the aforementioned study is to provide guidance with respect to the applicability and suitability of each configuration in predicting the performance of a bench-scale system. These results will allow us to establish a refined method for operation of the PyGC system to accurately screen catalyst functionality, operating conditions and biomass feedstocks.