A total of 49 fungal strains were evaluated in terms of their ability to degrade, decolorize and detoxify the wastewaters of the olive oil industry. Among the wood-rot fungi examined, S. hirsutum CCBAS 608, T. versicolor CCBAS 614 and T. lacteus CCBAS 616 produced most Ritonavir (0.12–0.14 g dry weight per 100 ml); in contrast, H. alpestre CCBAS 654, L. castoreus LGAM 898 and T. panuoides LGAM 899 exhibited the lowest mycelium production (0.02–0.04 g dry weight per 100 ml; Supplementary Fig. S1). Furthermore, I. nodulosus CCBAS556, L. edodes LGAM 887 and LGAM 897, M. excoriata LGAM 318 and P. eryngii LGAM 219 and LGAM 220 failed to grow in the OMW-based substrate and were not further studied. Considering the fact that other strains of L. edodes and P. eryngii ( D’Annibale et al., 2004, Koutrotsios and Zervakis, 2014 and Ntougias et al., 2012) were reported to produce abundant biomass in olive mill effluents, the inability of these particular species to grow in the frame of the present study indicates strain-specificity in OMW degradation.