As shown in Scheme the

As shown in Scheme 1, the magnetic PMADETA/PDVB IPNs was prepared by three continuous processes named suspension copolymerization, interpenetration and amination. OA-coated Fe3O4 nanoparticles were prepared by co-precipitation method [38] and dispersed in GMA (16.0 g) and DVB (4.0 g). GMA and DVB were copolymerized under N2 protection at 348 K for 12 h with the help of the initiator BPO (0.20 g), in which toluene (22.0 g) and n-heptane (8.0 g) were applied as the porogens, and hence the magnetic PGMA was prepared. According to Atazanavir typical interpenetration method performed in Ref. [3], 20 g of PGMA beads were firstly swollen by a mixture of DVB, toluene, n-heptane and BPO for 12 h, and the mass ratio of DVB to PGMA was 1:1. Toluene and n-heptane were employed as the porogens and carrageenan were 200% relative to DVB and the mass ratio of toluene to n-heptane was pre-set to be 4:1. The swollen magnetic PGMA beads were filtered from the mixture and added into 200 mL 0.05% of polyvinyl alcohol aqueous solution (w/v). At a moderate stirring speed, the temperature of the reaction mixture was raised to 368 K and the reaction mixture was kept at this temperature for 12 h. Thereafter, the obtained hydrophobic–hydrophobic magnetic PGMA/PDVB IPNs were chemically transformed to hydrophilic–hydrophobic magnetic PMADETA/PDVB IPNs via an amination reaction with superfluous DETA at 393 K for 12 h.