Energy intensive nature and limited flux are the major obstacles in successful and widespread commercial adoption of MD. A significant amount of heat is dissipated in the process due to temperature or thermal polarization characterized by the difference in temperatures at the membrane surfaces and in bulk phases . Among all the configurations, thermal polarization is the worst in DCMD which is the most studied configuration of MD. The effect of temperature polarization on flux AZD8055 in membrane distillation has been well acknowledged in numerous investigations ,  and . In addition to thermal polarization, surface scaling and organic fouling have also been found to depreciate MD performance as observed in various studies , ,  and . Hydrophobic nature of the membranes used makes duodenum more susceptible to organic fouling. Under high convective flux, concentration polarization can also play significant role in limiting the flux of the process.