Data quantifying the hydration practices of regular drivers is scarce, but assessments of hydration status and reported beverage intakes among employees in a variety of workplace settings highlighted that a significant proportion of employees report to work exhibiting signs of dehydration . A large proportion of those individuals also remained in a state of hypohydration at the end of their shift, citing restrictions on when and where they Lapatinib could consume fluid and access to toilet facilities as the primary barriers to increasing water intake. It is likely that driving in a hot car will lead to significant losses of water over the course of a long journey, but these data are not readily available in the scientific literature. Even in an air-conditioned car, evaporative water losses from the skin and lungs are likely to accumulate during a long drive due to exposure to dry air because of the increased vapour pressure gradient. Taking these points into consideration, the European Hydration Institute recommends the regular ingestion of non-alcoholic beverages during long automobile journeys to help to reduce road fatigue . These guidelines are likely to be sound, but anecdotal reports suggest that many drivers avoid drinking adequately, with a view to limiting the need for bathroom stops during long journeys.