Stem cell division can result in two sibling cells exhibiting differential mitogenic and self-renewing possible. Right here, we present proof the dual-specificity kinase Dyrk1A is portion of the molecular pathway involved with 5-HT Receptor signaling the regulation of biased epidermal growth issue receptor (EGFR) signaling from the progeny of dividing neural stem cells (NSC) of your adult subependymal zone (SEZ). We demonstrate that EGFR asymmetry calls for regulated sorting and that a usual Dyrk1a dosage is required to sustain EGFR while in the two daughters of the symmetrically dividing progenitor. Dyrk1A is symmetrically or asymmetrically distributed through mitosis, and biochemical analyses indicate that it prevents endocytosis-mediated degradation of EGFR Histamine H2 receptor by a mechanism that calls for phosphorylation from the EGFR signaling modulator Sprouty2. Ultimately, Dyrk1a heterozygous NSCs exhibit defects in self-renewal, EGF-dependent cell-fate choices, and long-term persistence in vivo, suggesting that symmetrical divisions play a part within the maintenance from the SEZ reservoir.