Stem cell biology holds terrific promise to get a new eramerely of cell-based treatment, sparking considerable interest between scientists, clinicians, and their patients. Having said that, the translational arm of stem cell science HIV-1 protease is inside a somewhat primitive state. Even though a variety of clinical scientific studies are initiated, the early returns point to quite a few inherent issues. On this regard, the clinical potential of stem cells can only be totally realized from the identification with the key barriers to clinical implementation. Here, we examine experimental paradigms to address the vital ways from the transition from stem cell biology to regenerative medicine, using cardiovascular sickness as a case examine.