Congenitally hypomyelinated shiverer mice fail to create compact myelin and die by 18-21 MAO weeks of age. Applying multifocal anterior and posterior fossa delivery of sorted fetal human glial progenitor cells into neonatal shiverer x rag2(-/-) mice, we accomplished complete neuraxis myelination with the engrafted hosts, which within a important fraction of circumstances rescued this otherwise ABT-199 mechanism lethal phenotype. The transplanted mice exhibited enormously prolonged survival with progressive resolution of their neurological deficits. Significant myelination in multiple regions was accompanied through the acquisition of standard nodes of Ranvier and transcallosal conduction velocities, ultrastructurally ordinary and comprehensive myelination of most axons, plus a restoration of the substantially usual neurological phenotype. Notably, the resultant mice have been cerebral chimeras, with murine gray matter but a predominantly human white matter glial composition. These data demonstrate the neonatal transplantation of human glial progenitor cells can effectively treat ailments of congenital and perinatal hypomyelination.