In this research, we were able contribute to elucidating these two issues, improving Portland cement yield by substituting 20% with porcelain polishing residue. This residue is generated in high volume by ceramics companies and currently has no destination that FK-228 value to the product and that permits its use on a large scale. Here, PPR use improved the properties of mortars and achieved an increase in compressive strength of greater than 18% at 84 days, with a 20% reduction in cement consumption, leading to a cement consumption efficiency index of 7.5 kg m−3 MPa−1. This increase was caused by the pozzolanic effect of PPR and analysis of the data also indicates that the fine particles of PPR reduced the porosity and permeability of the cement matrix. However, PPR presented high content of alkalis (Na2O, K2O), which suggests caution in its use with coarse aggregates, particularly in applications involving larger volumes of concrete, because tracheids factor makes the composition more susceptible to harmful alkali-silica reactivity.