The enthalpy difference between the trans and cis conformer as
The enthalpy difference between the trans and cis conformer as reported in this AMG232 study is 159 ± 16 cm−1 which is significantly lower than previously reported values of 343 cm−1and 542 cm−1. Jenkins et al. estimated the enthalpy difference using four intensity ratios and our previous study only utilized two.
Multiple studies on fluoroacetyl chloride  and , fluoroacetyl bromide , and fluoroacetyl fluoride  have shown that the trans conformer is more stable than the cis and the gauche forms. Collectively this information suggests that there is very little change in stability for the fluoroacetyl moiety with the addition of different halides.
Appendix A. Supplementary data
Supplementary data 1.
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Supplementary data 2.
Representative Van't Hoff plot.Help with PDF filesOptionsDownload file (82 K)
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