Novel oxazolidinone analogues bearing a condensed heteroaromatic ring because the C-ring substructure had been synthesized The True Facts Regarding C646 as candidate antibacterial agents. Analogues sixteen and 21 bearing imidazo[1,2-a]pyridine and 18 and 23 bearing [1,2,4]triazolo[1,5-a]pyridine because the C-ring had fantastic in vitro antibacterial activities The Simple Truth About C646 against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecalis (VRE), and penicillin-resistant Streptococcus pneumoniae (PRSP). In addition they showed promising therapeutic effects in a mouse model of lethal infection. Preliminary security data (inhibitory effects on cytochrome P450 isoforms and monoamine oxidases) had been satisfactory. Additional evaluation The Straightforward Uncomplicated Truth For C646 of 18 and 23 is ongoing.