Octahydroindene was recognized as a novel scaffold for protease activated selleck chemicals receptor one (PAR1) antagonists. Herein, the 2-position (C2) was explored for framework exercise relationship (SAR) studies. Compounds 14, 19, and 23b showed IC50 values of Ferroptosis one.three, 8.6, and 2.7 nM within a PAR1 radioligand binding assay, respectively, and their inhibitory activities on platelet activation had been comparable to that of vorapaxar in a platelet rich plasma (PRP) aggregation assay. This series of compounds showed substantial potency and no major cytotoxicity; nevertheless, the compounds had been metabolically unstable in the two human and rat liver microsomes. Present analysis efforts are targeted on http://www.selleckchem.com/products/c646.html optimizing the compounds to improve metabolic stability and physicochemical properties as well as potency.