The association between the maternal blood levels of dioxins at delivery and the risk of FYD, and babies with Usniacin hyperpigmentation, could not be investigated (Tsukimori et al., 2013). Among 64 women (117 births) who had their dioxin levels measured and gave complete information on their and their children's outcomes in 2009, the estimated maternal blood concentrations of dioxins (congeners of 7 PCDDs, 10 PCDFs, and 4 coplanar PCBs) at delivery were compared between babies with skin hyperpigmentation (n = 10) and babies without hyperpigmentation (n = 107). The estimated levels of these compounds were significantly associated with an increased risk of FYD, and in particular, the odd ratios that reflect the risk of FYD for a 10-fold increase in blood dioxin were largest for 1,2,3,6,7,8-hexaCDD (odds ratio = 28.6, 95% CI: 1.67–489.9).
3.6. Clinical studies
Kampo is a traditional herbal medicine, and each Kampo formula comprises several herbal extracts intended to increase the treatment effects and to diminish the adverse reactions of each herb. A clinical study of Kampo in Yusho patients (Uchi et al., 2011) revealed Kreb's cycle Bakumondo—to significantly improved respiratory symptoms as well as patients' quality of life in terms of their vitality, compared with other formulae. The Yusho Group is now preparing other clinical studies of Kampo to relieve symptoms in Yusho patients.