Fig. 31, Fig. 32 and Fig. 33 show the reservoir match results for a dual permeability and dual porosity approach using the upscaled model F2 by analytical and numerical approach. The dual permeability model using the numerical upscaling procedure is the best approach for this Axitinib case. Oda´s method overestimates the fracture permeability tensor value given the poor connectivity of fracture network. Given that, the oil recovery factor is lower for numerical upscaling approach since the time step related to flow progress in fracture medium is much smaller than the simulation time step required for full matrix-fracture fluid transfers, which justifies the oil that is left behind.