Nanowires have attracted much attention as materials for various applications, including high sensitivity sensors, and electronic and optical devices, because of their unique properties arising from their characteristic morphology ,  and . The vapor–liquid–solid (VLS) method is widely used to fabricate nanowires . VLS growth is based on the supersaturation of the reaction AZD2932 from eutectic droplets of the catalyst and reaction species. The droplets are formed by the interaction between the catalyst and reaction species. Many studies have explored the complicated VLS growth mechanism, with partial success , ,  and , and there are still aspects of the mechanism that are open to debate. Because VLS growth is a series of phase transitions in a tiny reaction space, its non-equilibrium state and shape factor should be taken into consideration. In particular, there are several definitions of the chemical potential, which is the driving force of the nanowire growth. In excretory system work, we explain the thermodynamics and kinetics of the reaction mechanism by investigating the phase transition driving force in the phase diagram of the catalyst and reaction species.