3.3.7. Method requirements
The most reliable biomarker measurements are obtained using instrumentation that can unambiguously identify and quantify the analyte of interest. The state-of-the-science instrument for measuring BPA is high performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS) (Ye et al., 2005); all seven publications used this methodology. Thus, all received a Tier 1 categorization. Although reviewers raised no issues regarding application of this SNG-1153 in the current assessment, we recommend that this be revisited using biomarkers measured using differing analytical methods.