X ray diffraction XRD analyses were

The Mutant IDH1-IN-1 spectra were obtained by the recording of 100 scans between 400 and 4000 cm−1 with a resolution of 4 cm−1. The powders were diluted in an analytical grade KBr (Janssens Chimica 99%) by a weight factor of 100, and then pressed into self-supporting disks before analysis. SEM micrographs were taken with a LEO 983 GEMINI microscope equipped with a field emission gun.