Phospholipids interact with surfactants and form mixed AZD-4547 ,  and . Being essential constituents of biological membranes, phospholipids are involved in various biological activities in living organisms  and . The knowledge of phospholipid-surfactant systems is important for many reasons, e.g., solubilization and reconstitution of biological membranes, isolation of membrane protein  and design of drug delivery systems . For this purpose a number of investigations have been carried out  and . These studies showed the breakdown of lamellar structures and the formation of lipid-surfactant mixed micelles. Litchenberg  postulated that the effective surfactant to lipid ratio producing liposome saturation and solubilization depends on the cmc of surfactants. Mixed micelles of surfactants and phospholipids have advantages as drug carrier over other carrier systems: they have hydrophobic core which can encapsulate hydrophobic drugs; have small size due to which they show an increased vascular permeability and accumulation in pathological areas with leaky vasculation. Mixed micellization of phospholipids with conventional surfactants is fairly well studied , , ,  and  but with gemini surfactants, the reports are scarce .