In some cases, more than 3 KNK437 of magnitude differences were observed (see Fig. 1 and Fig. 2). Discrepancies in Kow are typically larger for higher molecular weight compounds (more clearly shown in Figs. 3 and S1) for which solubilities in water reach extremely low levels. An analogous trend has been demonstrated for Sw and Ps for phthalate esters ( Cousins and Mackay, 2000) and Kow of PBDEs ( Cousins, 2013).