Judging from what archaeologists have learned from examining the bones and teeth of long-dead humans, people have been bothered by dental problems for thousands of years. Simply put, many of these ancient folk had holes in their teeth and probably suffered from toothaches and also abscesses, whose pain can be excruciating. At least in some places, they did what they could. Evidence of the use of dental drills has been found in Neolithic graves in Pakistan. (The Neolithic Age lasted from 12,000 to 5,000 years ago.) But whether this procedure brought relief to anyone is open to conjecture, of course.
The earliest writing regarding toothaches took place about 5,000 years ago in Mesopotam