A Sluggish ERK inhibitor's Way To Succeed

M.P. 130��C; IR (KBr): 3415, 3350, 3095, 2963, 1739, 1152cm?1; 1H NMR (DMSO-d6): 1.28 (t, 3H, CH3), 2.75 (s, 3H, CH3), 3.71 (s, 3H, The Lazy ERK inhibitor's Way To Make Money OCH3) 4.17 (q, 2H, CH2), four.73 (s, 1H, CH), 6.65�C6.95 (m, 4H, ArH), seven.03 (s, 2H, NH2), twelve.02 (s, 1H, NH) ppm. 13C NMR (400MHz, DMSO): 10.34, 13.62, 38.82, 55.68, 61.86, The Sluggish Prasugrel's Strategy To Do Well 78.72, 114.22�C132.38, 140.04, 156.22, 159.44, 160.36, 164.24ppm. Anal. calcd for C17H19N3O4: C, 62.00; H, five.81; N, 12.76. Located: C, 62.19; H, 5.79; N, twelve.75.Ethyl-6-amino-1,4-dihydro-3-methyl-4-(5-methylfuran-2-yl)pyrano[2,3-c]pyrazole-5-carboxylate(5f). M.P. 142��C; IR (KBr): 3427, 3365, 3077, 2949, 1739, 1166cm?one; 1H NMR (DMSO-d6): 1.22 (t, 3H, CH3), 2.17 (s, 3H, CH3), 2.75 (s, 3H, CH3), 4.17 (q, 2H, CH2), 4.73 (s, 1H, CH), 6.02�C6.28 (m, 2H, ArH), six.65�C6.95 (m, 4H, ArH), 7.

03 (s, 2H, NH2), 12.

02 (s, 1H, NH) ppm. 13C NMR (400MHz, DMSO): ten.32, 13.64, 14.2, 38.72, 61.83, 78.72, 114.22�C132.38, 140.04, 156.twenty, 159.40, 160.33, 164.20ppm. Anal. calcd for C15H17N3O4: C, 59.40; H, 5.65; N, 13.85. Located: C, 59.57; H, five.63; N, 13.86.Ethyl-6-amino-1,4-dihydro-3-methyl-4-(thiophen-2-yl)pyrano[2,3-c]pyrazole-5-carboxylate(5g). M.P. 115��C; IR (KBr): 3416, 3352, 3099, 2940, 1722, 1279cm?1; 1H NMR (DMSO-d6): 1.24 (t, 3H, CH3), two.72 (s, 3H, CH3), four.22 (q, 2H, CH2), 4.78 (s, 1H, CH), 6.60�C6.91 (m, 4H, ArH), six.69�C6.98 (m, 3H, ArH), seven.08 (s, 2H, NH2), twelve.04 (s, 1H, NH) ppm. 13C NMR (400MHz, DMSO): 10.38, 13.60, 38.80, 61.86, 78.72, 114.22�C132.38, 123.6�C139.4, 140.04, 156.22, 159.44, 160.36, 164.24ppm. Anal. calcd for C14H15N3O3S: C, 55.07; H, 4.95; N,13.76.

Discovered: C, 55.27; H, 4.

93; N, 13.77.Ethyl-6-amino-1,4-dihydro-3-methyl-4-(pyridin-3-yl)pyrano[2,3-c]pyrazole-5-carboxylate(5h). M.P. 125��C; IR (KBr): 3431, 3345, 3089, 2953, 1722, 1520cm?1; 1H NMR (DMSO-d6): one.28 (t, 3H, CH3), 2.75 (s, 3H, CH3), 4.17 (q, 2H, CH2), 4.73 (s, 1H, CH), 6.65�C6.95 (m, 4H, ArH), 7.08 (s, 2H, NH2), 7.29�C8.57 (m, 4H, ArH), (twelve.06 (s, 1H, NH) ppm. 143��C; IR (KBr): 3410, 3389, 3335, 3072, 2931, 1734cm?1; 1H NMR (DMSO-d6): 1.

30 A Lazy Prasugrel's Way To Succeed(t, 3H, CH3), 2.79 (s, 3H, CH3), four.

19 (q, 2H, CH2), 4.74 (s, 1H, CH), 5.02 (s, 1H, OH), 6.46�C6.54 (m, 4H, ArH), 7.06 (s, 2H, NH2), twelve.08 (s, 1H, NH) ppm.