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An expedient route for your synthesis Temozolomide of libraries of diversely decorated 2-aminopyrimidine-5-carbonitriles selleck screening library www.selleckchem.com/products/Bicalutamide(Casodex).html is reported. This strategy is based upon a three-component reaction followed by spontaneous aromatization.
A method involving a Mannich-type multi-component assembly procedure followed by a one,3-dipolar cycloaddition continues to be formulated for the fast and efficient building of parent heterocyclic scaffolds bearing indole and isoxazolidine rings. These important intermediates have been then readily elaborated making use of well-established protocols for refunctionalization and cross-coupling to accessibility a diverse 180-member library of novel pentacyclic and tetracyclic compounds linked to the Yohimbine and Corynanthe alkaloids. Many other new multicomponent assembly processes were produced to entry dihydro-beta-carboline-fused benzodiazepines, pyrimidinediones, and rutaecarpine derivatives.