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An efficient http://www.selleckchem.com/products/Axitinib.html and direct synthesis of 2-arylideneamino-3-aryl-4H-furo[3,2-c]chromen-4-ones continues to be produced by way of four-component reaction from substituted nitrostyrenes, aromatic aldehydes, coumarins, and ammonium acetate under Temozolomide incredibly mild circumstances, which consists of sequentially a Michael addition, an aza-nucleophilic addition, of your imine towards the double bond, an intermolecular nuclophilic addition in addition to a dehydration reaction. The resulting Bicalutamide cost biologically intriguing structures could have broad applications in linked biomedical-program structures.