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A series of hybrid compounds based mostly, on.(2R,3S)-N-benzoyl-3-phenylisoserine, artemisinin, and quinoline moieties was synthesized and examined for in vitro antiplasmodial exercise against erythrocytic stages of K1 and W2 strains of Plasmodium falciparum Two hybrid compounds Vincristine incorporating (2R,3S)-N-benzoyl-3-phenylisoserine selleck inhibitor and artemisinin selleck bio scaffolds had been 3- to 4-fold additional lively than dihydroartemisinin, with nanomolar IC50 values towards Plasmodium falciparum K1 strain.