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Onakpoya and colleagues performed a meta-analysis of 3 trials in which overweight participants received either 180 or 200 mg/day green coffee extract for four to 12 weeks 109 The researchers concluded that green coffee extract has a moderate but significant effect on physique weight (imply weight loss of two.47 kg far more than placebo), but they noted that the methodological high quality of all research incorporated in the meta-analysis was poor.
In this double-blind randomized study, stable outpatients with schizophrenia or schizoaffective disorder with a body mass index (BMI) ≥27 received 16 weeks of adjunctive metformin or placebo.