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We compliment Dr M��ller and colleagues [1] for their experiment around the protective role of simvastatin towards ventilator-induced lung injury (VILI). Their effects are in line with individuals of a appropriate research published a short while ago by our research crew; we also showed that pretreatment with statins (specifically atorvastatin) attenuates VILI [2]. By Aniracetam synthesizing the findings from the above contributions [1,2], a single could make numerous factors.Initial, provided that M��ller and colleagues administered simvastatin [1] even though we chose atorvastatin [2], it looks the observed benefit is actually a class-specific in lieu of a drug-specific impact; that is definitely, it may apply to the total class of statins. 2nd, the prevention of VILI by statins appears to not be species-specific; without a doubt, our colleagues employed mice [1], though we favored rabbits [2].

Third, although the initial examine utilised female animals [1] along with the second study employed male animals [2], there have been no differences within the made benefits; as a result, statins seem to be practical for the prevention of VILI in both sexes. This observation is vital offered the ongoing interest during the chance that drug responses may possibly vary by intercourse [3]. Fourth, by utilizing diverse necessary markers, both studies mentioned that administration of statins diminished VILI-associated hyperpermeability [1,2]. Indeed, the German group [1] utilised being a marker of lung permeability the human-serum-albumin bronchoalveolar lavage/plasma ratio, even though we used each lung edema and ultrafiltration coefficient (Kf, c).

Eventually, M��ller and colleagues implemented a 6-hour model of injurious mechanical ventilation to display that statins ameliorate pulmonary irritation [1], whereas we targeted over the quite acute phase of lung selleck chemicals DNA Synthesis inhibitor damage, when mechanical phenomena as an alternative to irritation may perhaps most effective explain the injury [2].In conclusion, we feel the two papers [1,2] mixed provide robust experimental evidence that a dose of statin as high as 20 mg/kg entire body fat administered before the induction of mechanical ventilation might protect towards VILI and pertinent clinical trials are as a result entirely justified.AbbreviationsVILI: ventilator-induced lung damage.Competing interestsThe authors declare that they have no competing interests.NotesSee connected exploration by M��ller et al., http://ccforum.com/content/14/4/R143