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Mice fed with OA have been resistant to sepsis, that has a 64% survival price at 168 hours compared with saline-treated mice (33%). OA supplementation in CLP-subject MG149 animals led to a significant decrease within the total leukocyte counts (ten.69 �� 106 �� 1.71), mostly neutrophils, in contrast with mice that acquired saline (20.30 �� 106 �� 2.69). However, in mice that consumed OA the ranges of TNF��, IL-10 and IL-6 have been not drastically distinct from mice fed with saline submitted to CLP. Interestingly, preliminary data showed that mice fed with OA had a lower degree of bacteria in the peritoneal lavage leukocyte compared with mice submitted to CLP. See Figure ?Figure11.Figure Artemisinin 1Bacterial count inside the peritoneal lavage leukocyte is reduced in oleic acid-treated mice submitted to CLP.ConclusionsOur data suggest Microtubule inhibitor purchase that treatment with OA lowers mortality in an experimental model of sepsis and attenuates inflammation. One particular mechanism concerned might be as a consequence of an elevated bacterial clearance in mice fed with OA. Extra data are essential to clarify this mechanism of increased survival.AcknowledgementsThis presentation was produced possible by partial assistance from CNPq, FIOCRUZ and FAPERJ.