In the present study, the treatment of polychlorinated phenols by MSFB application XCT790 presented for the first time. A freshly prepared Pd/Fe catalyst was entrapped in Ca2+ crosslinked Na-alginate beads enabling retention and protection of the catalyst, and a continuous 2,4,6-TCP dechlorination process operation within the MSFB reactor. The kinetics of Pd/Fe catalyst-promoted 4-CP, 2,4-DCP, 2,6-DCP and 2,4,6-TCP dechlorination processes was preliminarily studied in a batch system in order to obtain kinetic parameters for each individual reaction step. Subsequent experiments were conducted to examine 2,4,6-TCP dechlorination reactions within an MSFB using alginate beads with entrapped Pd/Fe catalyst. The resulting data were employed to evaluate a detailed mathematical model of the MSFB-assisted dechlorination process, by accounting for mass transfer in the bulk solution (convection), transport within the alginate beads with the catalyst (diffusion), and hydrodehalogenation reaction kinetics including catalyst deactivation. The resulting mathematical model of the dechlorination process in the MSFB, based entirely on first principles, is experimentally verified. Thus, numerical simulations based on the mathematical model developed in this study can be used as an engineering design tool for future systems operating under a variety of experimental conditions in the MSFB-assisted process for treatment of contaminated soil or sludge slurries.