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Around the bases of patent [15] published by Ketoconazole Quan from China metrology institute, the writer of this paper namely does study and develops mixture gadget of supercritical fluid extraction and quick growth of supercritical answer, which is named as supercritical fluid extraction and expansion (SFEE). SFEE has extraction and granulation functions and can be utilized individually or mixed. Stearic acid is usually a sort of important industrial raw materials, which is widely used in manufacturing cosmetics, plastic hardy plasticizer, release agent, stabilizer, surfactant, rubber vulcanization agent, waterproofing agent, brightener, metallic soap, softener, pharmaceuticals, and other natural chemicals. You will discover different existing mature ways for stearic acid in industrial production; It's a new attempt and strategy to make use of SFEE technologies for getting stearic acid particles.



On this research, the feasibility with the SFEE system around the micronization of stearic acid was investigated. Examinations of your solid-state properties such since the particle dimension and its distribution, too as the purity alter of stearic acid after processing by SFEE, which is, stearic acid solubility inside the CO2 SCF, are demonstrated.two. Experimental Method2.1. MaterialsStearic acid granules (C18:0FFA) that has a indicate particle diameter of about four.5mm with purity about 60% was supplied by Qinghongfu Technologies Co. (Beijing China). Liquid www.selleckchem.com/products/Pemetrexed-disodium.htmlcarbon dioxide with purity of 99.9% applied for SFEE course of action was obtained from Praxair Gas Co. (Beijing, China).2.two.

Apparatus and ProcedureThe schematic diagram of your SFEE procedure is proven in Figure 1.

The experimental apparatus on this paper was designed by the investigation crew, primarily 5 parts included: pressure management unit, temperature control unit, injection unit, extraction unit, and expansion unit. Before the commence on the experiment, three temperatures of temperature management unit should be set: pump cooling unit (purchased from Hengping instrument, Shanghai) adjusted to 276K and extraction unit and growth unit temperature set towards the necessary temperature. Preextraction temperature (extraction oven temperature) and growth temperature (expansion oven temperature) are heated controlled by incubator (our staff formulated it with Beijing Luxi technologies with each other), that is formed from two chambers, resulting in temperature, respectively, managed, without interference.



Figure 1Process movement diagram. X0101 purifier; E0101 heat exchanger; P0101 CO2 pump; P0102 entrainer pump; V0101 mixer; X0102 purifier; E0102 heat exchanger; X0103 incubator; X0104 incubator; T0101 extraction oven; T0102 growth oven; X0105 nozzle.SCF-CO2 pressure is mostly provided by supercritical unique high-pressure pump (provided by Thar), that is managed from the back strain valve (provided by Tescom).