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We compliment Dr M��ller and colleagues [1] for their experiment about the protective role of simvastatin against ventilator-induced lung injury (VILI). Their outcomes are in line with these of the relevant examine published lately by our analysis workforce; we also showed that pretreatment with statins (exclusively atorvastatin) attenuates VILI [2]. By DNA Synthesis signaling inhibitor synthesizing the findings in the above contributions [1,2], one could make numerous factors.Initially, offered that M��ller and colleagues administered simvastatin [1] while we chose atorvastatin [2], it appears that the observed benefit is actually a class-specific in lieu of a drug-specific result; that is, it might apply to your full class of statins. Second, the prevention of VILI by statins seems not to be species-specific; indeed, our colleagues employed mice [1], even though we favored rabbits [2].

Third, when the initial study used female animals [1] along with the second study employed male animals [2], there were no differences within the generated effects; hence, statins appear to be handy for your prevention of VILI in each sexes. This observation is essential provided the ongoing interest while in the possibility that drug responses might differ by intercourse [3]. Fourth, by using diverse MI-3 (Menin-MLL Inhibitor) markers, both research mentioned that administration of statins lowered VILI-associated hyperpermeability [1,2]. Without a doubt, the German group [1] used as being a marker of lung permeability the human-serum-albumin bronchoalveolar lavage/plasma ratio, even though we utilised the two lung edema and ultrafiltration coefficient (Kf, c).

Lastly, M��ller and colleagues implemented a 6-hour model of injurious mechanical ventilation to show that statins ameliorate pulmonary irritation [1], whereas we centered within the really acute phase of lung Aniracetam damage, when mechanical phenomena rather then irritation could very best clarify the injury [2].In conclusion, we think that the two papers [1,2] combined supply sturdy experimental evidence that a dose of statin as high as 20 mg/kg body excess weight administered before the induction of mechanical ventilation may well shield towards VILI and appropriate clinical trials are hence totally justified.AbbreviationsVILI: ventilator-induced lung damage.Competing interestsThe authors declare that they have no competing interests.NotesSee associated investigation by M��ller et al., http://ccforum.com/content/14/4/R143