Rosuvastatin reduced LDL cholesterol ranges by 50% and high-sensitivity C-reactive protein amounts by 37%. The charges of the major finish stage had been 0.77 and 1.36 per one hundred person-years of follow-up while in the rosuvastatin and placebo groups, respectively (hazard ratio for rosuvastatin, 0.56; 95% self confidence interval [CI], selleck kinase inhibitor 0.46 to 0.69; P < 0.00001), with corresponding rates of 0.17 and 0.37 for myocardial infarction (hazard ratio, 0.46; 95% CI, 0.30 to 0.70; P = 0.0002), 0.18 and 0.34 for stroke (hazard ratio, 0.52; 95% CI, 0.34 to 0.79; P = 0.002), 0.41 and 0.77 for revascularization or unstable angina (hazard ratio, 0.53; 95% CI, 0.40 to 0.70; P < 0.00001), 0.45 and 0.85 for the combined end point of myocardial infarction, stroke, or death from cardiovascular causes (hazard ratio, 0.53; 95% CI, 0.
40 to 0.69; P < 0.00001), and 1.00 and 1.25 for death from any cause (hazard ratio, 0.80; 95% CI, 0.67 to 0.97; P = 0.02). Consistent selleck chem inhibitor effects were observed in all subgroups evaluated. The rosuvastatin group did not have a significant increase in myopathy or cancer but did have a higher incidence of physician-reported diabetes.ConclusionsIn this trial of apparently healthy persons without hyperlipidemia but with elevated high-sensitivity C-reactive protein levels, rosuvastatin significantly reduced the incidence of major cardiovascular events. (ClinicalTrials.gov number, NCT00239681.)CommentaryIt is well known that statins reduce the risk of myocardial infarction, stroke, and death from cardiovascular events in patients with established vascular disease and in those with risk factors, such as diabetes or hyperlipidemia.
Nevertheless, half of all myocardial infarctions and strokes come about between otherwise balanced men and females Cilnidipine without having regarded vascular sickness or risk variables . Inflammation is considered to play a central position from the development and progression of vascular illness. In addition to their lipid-lowering results, statins have anti-inflammatory properties, minimizing ranges of high-sensitivity C-reactive protein (hsCRP), an acute-phase protein located from the blood that rises in response to inflammation. HsCRP level is actually a stronger predictor of cardiovascular occasions than the LDL cholesterol degree and that it adds prognostic data to that conveyed through the Framingham threat score .