Proviron (mesterolone) is an interesting anabolic steroid, though it is not of much worth to bodybuilding. It seems that the most typical reason for many to consider including it in a steroid stack is for anti-estrogenic activity. In the days before anti-aromatases and the usage of SERMs (selective estrogen receptor modulators) such as Clomid and Nolvadex, there was some value to this.
An quantity of aromatizing steroid marginally over the amount that would be tolerable without Proviron became tolerable with the inclusion of it. Nevertheless, the result is really just borderline, and much better anti-estrogenic agents now exist. When all these are used, there's no need for Proviron as an anti-estrogen.
The mechanism by which it's some effectiveness in this regard is from binding weakly to the estrogen receptor without activating it, and to the aromatase enzyme. In the very first case, this partly reduces the amount of receptor sites momentarily available to bind estrogen, so reducing estrogenic activity. In the 2nd case, some fraction of aromatase molecules at any certain moment are unavailable to bind and convert testosterone, the' sites being occupied with mesterolone.
The 2nd most common reason is most likely to address a fear that libido may be lost without it. It is a fact that when added to standard androgen levels, Proviron has an androgenic effect that in many cases improves libido. However, most anabolic steroids also have this same property. In a steroid cycle, adding Proviron accomplishes nothing further. Or in the case of anabolic steroids such as nandrolone (Deca) which for other reasons may adversely affect libido, Proviron supplies no greater help against that than do various other anabolic steroids.
One of many fascinating things about Proviron is that while it assays (tests) as being an powerful anabolic in the rat, it is almost useless for building muscle in man. This might be caused by increased conversion in muscle tissue to the diol, but it might instead be a result of some unknown reason.
Another fascinating thing is it loves some practical use as a pro-sexual agent inbetween cycles. Normally 50 mg is taken shortly before improved performance is expected to be helpful.
Contrary to common belief, Proviron Purchase is some what inhibitory of the HPTA. Using it during the recovery phase as part of post-cycle therapy is counterproductive. It is also inadvisable for this reason to use it constantly while intending to be off-cycle, but occasional recreational use presents no difficulty.
Proviron has been utilized in female bodybuilding, but it's almost certainly the worst ratio of anabolic effect to virilizing effect of any anabolic steroid in common use. The perceived worth is in fat loss and hardening, but friendlier alternatives exist for this. Most of that worth is from anti-estrogenic effect, which Nolvadex may also accomplish. And for an androgen component, there are better options, including Primobolan.
Unlike almost all other orals, Proviron is not hepatotoxic, as it is not 17-alkylated.
Tablets are commonly 25 mg, and taken one or two at a time. Amounts greater than this have no additional effect on enhancing libido off-cycle, but if used for a particular occasion, whether on-cycle or off-cycle, may temporarily improve vascularity, if it is already noticeable but has room for advancement.
Mesterolone is the chemical name of active ingredient in Proviron. Proviron was a registered trademark of Schering AG in the USA and other nations prior to cancellation.