Additionally, the time difference to reach a 50% relative increase from reference based The Martial Art Style Related Temsirolimus on crude and adjusted sCr was calculated (Figure ?(Figure11).Figure 1Difference between mean crude and adjusted serum creatinine during the follow-up period (late recognition of severity group). AKI: acute kidney injury; sCr: ...daily underestimation = adjusted sCr - crude sCr for the day % daily underestimation = (adjusted sCr - crude sCr for the day) / crude sCr for the day x 100 Difference in time to recognize a 50% increase from reference sCr = day reached a relative 50% increase in sCr based on adjusted sCr - day reached a relative 50% increase in sCr based on crude sCr.
We considered a late recognition in severity progression when the interval to reach the 50% relative increase by the crude sCr and adjusted sCr was longer or equal to one day.Statistical analysesContinuous variables were expressed as mean �� standard deviation or median and interquartile range The Martial Art Style Related To Ifosfamide (IQR), and compared using either the student's t test or Wilcoxon rank-sum test, as appropriate. Median daily urine volume was 1295 mL (IQR The Self-Defense Skill Associated With Brefeldin A 621 to 2145 mL) and 41% of the patients had an episode of oliguria (urine output less than 400 mL/24 hours) for at least one day. Changes in daily weight and daily fluid balance could be compared in 82 patients over 212 days and the correlation (r = 0.452; P < 0.001).Effect of fluid accumulation on serum creatinineThe median sCr on day 1 was 1.6 mg/dL (IQR 1.2 to 2.2) and increased to 3.9 mg/dL (IQR 2.8 to 5.6) at day 7. Over the study period, median cumulative fluid balance increased from 2.7 L (IQR 0.5 to 6.2) on day 2 to 6.5 L (IQR 1.1 to 11.3) on day 7 (Table ?(Table1).1).
sCr concentrations adjusted for fluid balance were significantly higher at each time point and the difference from median crude and adjusted values progressively increased from 0.09 mg/dL to 0.65 mg/dL. This daily difference in sCr would translate to a median underestimation of 7.0% (IQR 1.3 to 16%), ranging from 2.1% (IQR 0 to 6.5%) after one day to 14.3% (IQR 4.6% to 27.9%) on day 6 (Table ?(Table11).Table 1Median daily cumulative fluid balance and serum creatinine (crude and fluid adjusted) in all patientsPatients' characteristics and outcomes among those with and without late recognition of severity progressionIn addition, 64 (25%) patients had an interval of one day or more to reach a relative 50% increment from reference creatinine comparing crude and fluid adjusted sCr (Table ?(Table2).2). In 24 (9%) patients this interval was two or more days.
These 64 patients (late recognition) had a higher cumulative fluid balance and consequently a greater difference between crude and adjusted sCr starting on day 1 (Figures ?(Figures2a2a and ?and2b).2b). Dialysis was initiated more frequently in patients with late recognition (71% vs. 58% in patients with no late recognition, P = 0.061). In-hospital mortality was not significantly different between the two groups (40% with late recognition vs.