Microcirculatory dysfunction (MD) Etodolac, ICI-182780, unfortunately has previously been experimentally assessed, notably by measuring neurovascular coupling.
This consists of assessing adjustments in cortical movement velocity during somatosensory activation . Interestingly, this MD preceded each neurophysiologic and macrocirculatory alterations, indicating that it is an early phase inside the pathogenesis of SAE. Taccone and colleagues  present a convincing visual demonstration of this phenomenon. Working with cortical videomicroscopy in an ovine peritonitis model, they discovered proof of a reduced density of perfused and functional capillaries.