Microcirculatory dysfunction (MD) Fulvestrant, Etodolac, Rho pathway has previously been experimentally assessed, notably by measuring neurovascular coupling.
This includes assessing alterations in cortical movement velocity in the course of somatosensory activation . Interestingly, this MD preceded each neurophysiologic and macrocirculatory alterations, indicating that it truly is an early phase in the pathogenesis of SAE. Taccone and colleagues  provide a convincing visual demonstration of this phenomenon. Applying cortical videomicroscopy in an ovine peritonitis model, they identified proof of the reduced density of perfused and practical capillaries.