Patients' thromboembolic occasions like myocardial infarction, cerebrovascular condition, deep venous thrombosis and pulmonary thromboembolism, and arteriovenous fistula issues (like thrombus, emboli, or clotting) have been analyzed this and recorded from the one-year followup. Review group was divided into two equal sized groups as higher (n: 42) and reduced viscosity selleck chemicals groups (n: 42) for statistical examination. Then these two groups have been in contrast with every other in means of demographical and biochemical traits. rHuEPO hyporesponsiveness was defined as rHuEPO prerequisites >150U/kg/week to realize a target hemoglobin degree of 11-12g/dL. We classified patients receiving rHuEPO (>150U/kg/week) as hyporesponsive (n: forty), minimal dose rHuEPO (75�C300U/kg/week) (n: 23), and no rHuEPO (n: 21) groups.
Statistical AnalysisStatistical analyses had been carried out by using SPSS software (Statistical Package for that Social Sciences, edition 11.0, SSPS Inc., Chicago, IL, USA). Normality of data was analyzed by utilizing a Kolmogorov-Smirnov check. All numerical variables with typical distribution have been expressed because the usually means �� typical deviations (SD), even though variables with skew distribution had been expressed as medians and interquartile selection (IR). Categorical variables had been expressed as percentages and compared by chi-square check. Ordinarily distributed numeric variables had been analyzed by independent Ondansetron HClsamples t- or one-way ANOVA (publish hoc Tukey) tests according to distribution normality. Skew distributed numeric variables had been in contrast utilizing the Mann-Whitney U and Kruskal-Wallis exams according to distribution normality.
Spearman and Pearson Correlation tests were utilized for correlation analyses. A P worth <0.05 was considered as statistically significant.3. ResultsDemographic and biochemical characteristics of study groups are summarized in Table 1. Plasma viscosity of whole study group was 2.52 �� 0.65 (range 1.6�C3.9) mPas. Plasma viscosity was positively correlated with duration of MHD (r: 0.287, P: 0.008, Figure 1). Comparison of high and low viscosity groups revealed that patients with high viscosity had longer MHD history (133.2 �� 77.1 versus 97.5 �� 83.1 months, P: 0.044), higher calcium (9.51 �� 0.61 versus 9.13 �� 0.65mg/dL, P: 0.009), phosphorus (5.18 �� 0.8 versus 4.71 �� 1.09mg/dL, P: 0.035), calcium �� phosphorus product (49.37 �� 9.
39 versus 43.45 �� eleven.four, P: 0.
011), and greater rHuEPO necessity (356.four (295.7) versus 204.two (350.8) U/kg/week, P: 0.006, Table 2). rHuEPO hyporesponsiveness was also more typical in hyperviscosity group (28/42, 66.7% versus 13/42, 31%, P: 0.004). these of Individuals with hyperviscosity had higher rHuEPO/Hb levels (P: 0.021). In hyperviscosity group the rHuEPO specifications of individuals had been increased (28/42, 66.7% versus 13/42, 31%, P: 0.004) than patients obtaining decrease viscosity. Figure 1Plasma viscosity was positively correlated with patients' hemodialysis duration (r: 0.287, P: 0.008).