Fibrosis frequently develops as an own entity on the basis of most common pro-fibrotic co-morbidities like obesity, diabetes, non-alcoholic fatty liver disease) chronic kidney disease, idiopathic pulmonary fibrosis, or cardiomyopathy and is a key determinant for progression into diseases like liver cirrhosis, end-stage renal disease, lung fibrosis or even cancer. These diseases are to a large extend associated with a “Western life style” where dietary caloric intake has increased and KNK437 expenditure has been reduced. Moreover, a lot of changes in the food composition with polyunsaturated fatty acids, excess proteins and cereals have been observed. In addition, chronic alcoholism and tobacco smoking increased severely keeping pace with ever worsening environmental toxicity. Thus, our established antioxidant capability is confronted with more difficulties than it is supposed to encounter, underpinning, at least in part, increased occurrence of the above mentioned diseases and fibrosis.