Morphology of the MAR-MPs. (a) SEM image of crystal MAR. Scale bar AZD 8055 10μm. (b) ...
Morphology of the MAR-MPs. (a) SEM image of crystal MAR. Scale bar is 10 μm. (b) Optical image of MAR-MPs before solvent extraction, Scale bar is 100 μm. (c) Optical image of MAR-MPs after solvent extraction, Scale bar is 100 μm.
Morphologies of MAR-MPs. SEM images of (a) P1, (b) P2, (c) P3, and (d) P4 ...
Morphologies of MAR-MPs. SEM images of (a) P1, (b) P2, (c) P3, and (d) P4 MAR-MPs. (e) Size distribution and (f) mean diameter of MAR-MPs. Data are represented as mean ± S.D. (n = 3).
3.2. Hydrophilicity of MAR-MP
POL was reported as a polymer that enhances the permeability of water to the inner part of the particle and POL content in formulation could provide controlled drug release . Therefore, the hydrophilicity of the composition was measured by water contact angle. The water contact angles of the P2, P2L20, P2L50, and P2L100 MAR-MPs were 64.8 ± 0.6°, 47.6 ± 1.1°, 39.9 ± 3.2°, and 7.4 ± 1.6° respectively (Fig. 4). These results indicated that polymer composition with a higher ratio of POL to PLGA was more hydrophilic. POL is blended with the PLGA matrix that has polyethylene oxide chains, which provide a hydrophilic nature to the matrix and decrease the surface free energy of the polymer matrix against water phase .