The results of this Sotrastaurin study need confirmation from other studies but suggest a weak teratogenic effect of tramadol, specifically with respect to cardiovascular defects and pes equinovarus. To conclude, until further information is available, avoidance of tramadol use during early pregnancy may be recommended. If exposure has occurred, the absolute risk is small and the malformations observed are not very serious why there is little reason to discuss an interruption of pregnancy because of such exposure.
The prostate is an accessory gland in the reproductive tract and its main function includes the production of a glycoproteic secretion that is responsible for the maintenance of nutrition and the survival of the spermatozoon and the promotion of coagulation and liquefaction of the semen . This non-male exclusive gland can be also found in females of mammals other than humans: the primates, rodentia, carnivora, and lagomorfa , ,  and .
The prostate gland arises from the endodermal urogenital sinus (UGS) during morphogenesis as urogenital epithelial (UGE) cells penetrate into the surrounding urogenital sinus mesenchyme (UGM) ,  and . The UGS is present in mammals of both genders and occurs between fetal days 16.5 and 17.5 in mice, and at fetal day 18.5 in rats .