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004), PaO2/FiO2 (84.8 �� 49 mm Hg versus 176.0 �� 116 mm Hg; P = 0.008), LIS CPI-613 purchase (3 [IQR = 2.3 to 3.6] versus 2 [IQR = 1 to 2.3]; P = 0.003), PEEP (8 cm H2O [IQR = 6 to 10 cm H2O] versus 5 cm H2O [IQR = 4 to 9 cm H2O]; P = 0.17), and pleural effusion (550 mL [IQR = 370 to 850 mL] versus 500 mL [IQR = 300 to 865 mL]; P = 0.22).Table 1Patient characteristicsNo difference in lung weight was demonstrated between patients whose autopsy was started within 24 hours (early group; n = 20, 1,315 g [IQR = 1,270 to 1,600 g]) and those whose autopsy was started later than 24 hours (late group; n = 10, 1,320 g [IQR = 930 to 1,757 g]) (P = 0.79).CPR was performed in 16 cases (53%). Median lung weights were 1,285 g (IQR = 950 to 1,672 g) in the CPR group and 1,430 g (IQR = 1,200 to 1,620 g) in the non-CPR group.

There was no statistical difference between the groups (P = 0.59).Reproducibility of EVLW measurementsThe CV of EVLW measurement in the present study was 7.4%. ICC (1, 1) and ICC (1, 3) of EVLW measurement in the present study were 0.97 and 0.99, respectively.Correlation between single-indicator EVLW selleck chem GABA Receptor inhibitor and postmortem lung weightWe found a very close correlation between transpulmonary measurement of EVLW and postmortem lung weight (r = 0.904; P < 0.001) (Figure (Figure1).1). The linear regression equation for correlation was as follows:Figure 1Correlation of extravascular lung water (EVLW) measured by single transpulmonary thermodilution and by postmortem lung weight. EVLW (in milliliters) = [0.56 �� lung weight (in grams)] - 58.0. n = 30, r = 0.90, P < 0.001. Line of identity ...

EVLW (in milliliters)=[0.56��lung weight (in grams)]?58.0.(1)For the correlation between transpulmonary measurement of EVLW and postmortem lung weight, no significant difference was observed between sexes (males: n = 24, r = 0.846, P < 0.001; Malotilate females: n = 6, r = 0.943, P = 0.005; difference of correlation coefficient: P = 0.72). Furthermore, no significant difference was found between patients whose pleural effusion amounts were less than or more than 500 mL (��500 mL: n = 13, r = 0.89, P < 0.001; >500 mL: n = 17, r = 0.92, P < 0.001; difference of correlation coefficient: P = 0.13); between low- and high-LIS patients (LIS ��2.5: n = 18, r = 0.84, P < 0.001; LIS >2.5: n = 12, r = 0.95, P < 0.001; difference of correlation coefficient: P = 0.27); or between high- and low-CI patients (CI >2.

5 L/min per m2: n = 20, r = 0.84, P < 0.01; CI ��2.5 L/min per m2: n = 10, r = 0.96, P < 0.01; difference of coefficient of correlation: P = 0.65). Very close correlations were demonstrated with both the high-CVP group (>12 mm Hg; n = 13, r = 0.94, P < 0.01) and the low-CVP group (��12 mm Hg; n = 17, r = 0.89, P < 0.01), with no statistical difference in coefficient of correlation (P = 0.12). Very close correlation was also demonstrated between the high-PEEP group (>10 cm H2O; n = 9, r = 0.95, P < 0.01) and the low-PEEP group (��10 cm H2O; n = 21, r = 0.87, P < 0.