Metronidazole found in the anaerobic bacteria resistant since 1960, has been widely used in clinical. In recent years is given priority to with metronidazole medicine in the treatment of rosacea, acne and other topical formulations and made into burn release.it and cosmetics applications on the rise. We also noticed that is added in the external preparation of dermatology, transdermal absorption promoting agent can obviously improve the clinical curative effect. From the completed work suggests that Laurocapram(Azone) Skin Penetration of metronidazole and propylene glycol have obvious effect on promoting Skin Penetration.
Transdermal absorption promoting agent appear ceaselessly, make external preparation efficacy was improved, also greatly reduces the cost, increase its use of security. Laurocapram(Azone) Skin Penetration was developed in the 80 s a new type of high efficient transdermal absorption promoting agent, it is by increasing the stratum corneum lipids flow and dissolve Skin lipids to increase the transdermal absorption of drugs. Its characteristic is colorless, odorless non-toxic, produces stimulation to the human body mucous membrane lower limit. Although its cost is higher, but still widely used in many pharmaceutical preparations. And menthol is a single terpenoids, both at home and abroad has been reported in the literature as a single terpenoids have effect on promoting skin penetration, menthol
(Azone Laurocapram) Skin Penetration Enhancer in transdermal effect of found for single terpenoids transdermal absorption of research provides an important clue.