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For this objective, 2011 was defined as 0.92 years (eleven of 12 months; Melatonin January�CNovember). Table 2 exhibits the eleven posts with most citations per year (numerous had 28 annual citations, which was the minimal quantity expected for this endpoint). The table includes articles or blog posts published involving 1990 and 2009, but none on the 2010 publications had accumulated sufficient citations. 6 on the posts reported on randomized clinical trials. Precisely the same amount of publications covered surgical or radiosurgical approaches and three brain metastases in individuals with breast cancer. Figure 5Minimum quantity of citations required for being between the 5 most cited posts in a offered year.Table 1Articles with most citations (absolute count).Table 2Articles with most citations per year.

Overall, thirty randomized clinical trials had been published among 1990 and 2010, which includes individuals with phase II layout and excluding duplicate publications, for example, soon after longer followup or with focus on secondary endpoints. Ten of these were published following 2008. Their median variety of citations was 13.5, range 1�C82. Twenty randomized clinical trials were published just before 2008. Their median quantity of citations was 110, array 13�C1013. Probably the most cited content articles (major five of each 12 months [10�C116]) had been published in 35 unique scientificselleck chemical journals. Twenty-five articles or blog posts (23%) have been published during the Worldwide Journal of Radiation Oncology, Biology, Physics, 14 (13%) inside the Journal of Clinical Oncology, twelve (11%) in Cancer, 9 (8%) in the Journal of Neurosurgery, and 6 (6%) inside the Journal of Neuro-Oncology.four.

DiscussionThis overview is based mostly on the systematic literature search the place we decided to apply a broad definition of brain metastases-related publication. It must be kept in thoughts that not all finished exploration projects sooner or later might be published. We acknowledge that a lot of the selected content articles is likely to be topic to debate. Within this overview, we centered on citation price. Posts with substantial numbers of citations are probably people that impressed other clinicians/scientists and had profound influence on clinicalthorough practice or long term developments while in the field. Even so, the vast majority of published content articles reviewed here acquired restricted awareness (22% were not cited at all). In a research covering the Lancet, JAMA, and New England Journal of Medication, from October 1999 to March 2000, the authors uncovered that presence of market funding and an industry-favoring result was related with a rise in yearly citation rate of 25.

7 (95% confidence interval, eight.5 to 42.8) in contrast towards the absence of the two industry funding and industry-favoring results [117]. Higher annual charges of citation have been also linked with posts managing cardiovascular medication (13.3 more; 95% confidence interval, three.9 to 22.3) and oncology (twelve.six much more; 95% self confidence interval, 1.2 to 24.0), articles or blog posts with group authorship (11.1 much more; 95% self confidence interval, 2.seven to 19.five), larger sample size and journal of publication.