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Statistical significance was established by Pearson chi-square test. Variations of P<0.05 were considered to be statistically significant different. Results 1. Prevalence of AGC Among 54,160 subjects who received a Pap smear, the number during of patients with AGC, AGC-NOS, and AGC-favor neoplastic cells was 83 (0.15%), 55 (0.10%), and 28 (0.05%), respectively. Of the examination performed, conventional Pap smear and liquid-based Pap (ThinPrep) were carried out in 51,510 subjects (95.1%) and 2,650 subjects (4.9%), respectively. In conventional Pap smear, AGC, AGC-NOS, and AGC-favor neoplastic were present in 64 (0.12%), 41 (0.08%), and 23 subjects (0.04%), respectively; in liquid-based Pap (ThinPrep), AGC, AGC-NOS, and AGC-favor neoplastic were observed in 19 (0.72%), 14 (0.53%), and 5 subjects (0.
19%), respectively (Table one). two. Qualities and clinicopathologic DOCK9 correlation of the sufferers with AGC-NOS and AGC-favor neoplastic The average age on the female individuals was 47.3 �� seven.eight years outdated for AGC-NOS, 51.9 ��10.one years old for AGC-favor neoplastic, and 49.two �� 8.89 many years previous for AGC. AGC-NOS represented 3.35 ��1.9 times the typical gravidity and one.79 ��1.0 occasions the common parity; AGC-favor neoplastic represented 5.15 �� two.4 instances the common gravidity and two.51 ��1.2 instances the typical parity; and AGC represented 3.91�� 2.3 times the typical gravidity and two.01��1.1 times the average parity. For AGC-NOS circumstances, HPV examination was carried out in sixteen subjects out of 55 cases; in which 5/16 (31.2%) topics (sort 33, 1 subject; type 52, one subject; and form 53, two subjects) had been deemed at substantial possibility of infection and 1/16 (6.
3%) subjects (type six, 1 topic) had been deemed at minimal risk of infection. During the case of AGC-favor neoplastic, evidence of the high threat of infection was found in 5/10 (50.0%) subjects (form 18, one subject; variety 33, two subjects; screening library form 35, 1 topic; type 53, 1 subject). In patients with AGC, substantial danger and reduced chance of HPV infection was current in 9/26 (34.6%) topics and 1/26 (three.8%) topics, respectively. Through diagnosis, the CA-125 (U/mL) average was 24.4 �� 36.five (U/mL) in 31 AGC-NOS situations, 97.six ��155.4 (U/mL) in 19 AGC-favor neoplastic scenarios, and 50.8 ��101.six for AGC instances (Table 2). three. Histologic correlation of AGC-NOS and AGC-favor neoplastic Histologic results and clinical findings diagnosed through follow-up inside the patients with AGC-NOS and AGC-favor neoplastic had been described as follows.
For AGC-NOS instances, benign pathology indicated by typical histologic findings or benign disease was observed in 34/55 (61.8%) topics; low grade squamous intraepithelial lesion, large grade squamous intraepithelial lesion, carcinoma in situ, adenocarcinoma in situ, and endometrial hyperplasia, which corresponded to pre-malignancy, were uncovered in 13/55 (23.6%) subjects; and malignant pathology was observed in 8/55 (14.6%) subjects.