NSAIDS ( Non Steroidal Anti-Inflammatory Drugs) are analgesics used to manage fever (pyresis), inflammation, and pain(as a result of inflammation). Examples of NSAIDS include: Aspirin, naprosyn, Diclofenac etc.
BRIEF MECHANSIM OF NSAIDS
NSAIDS, like all other pain killers, work by inhibiting the synthesis of prostanglandins. Arachidonic acid is produced by the action of the enzyme, phospholipase A2 on phospholipids. The arachidonic acid produced then undergoes two different pathways: the cox-pathway and the lox-pathway.
In the cox- pathway, arachidonic acid is converted to prostanglandin H2 by the action of the enzyme cyclo-oxygenases. The prostanglandin H2 is then acted upon by prostanglandin synthase to produce prostacyclin, thromboxane A2(together called, PROSTANOIDS).
Also in the lox-pathway, arachidonic acid is acted on by lipo-oxygenases which converts it into leukotrienes namely '; LTB4, LTD4 etc.