Conclusion AcknowledgmentThe author would like to

4. Conclusion
AcknowledgmentThe author would like to acknowledge Dr. N. A. negm, Professors of Petrochemicals, Egyptian Petroleum Research Institute, for their encouragement in the '3X preparation of this work.
The rate of the 3X FLAG of norfloxacin by CTAP in acetonitrile–water binary solvent mixture is primarily controlled by the preferential solvation of reactant and the transition state through specific and nonspecific solute–solvent interaction.Figure optionsDownload full-size imageDownload as PowerPoint slide
Norfloxacin; Oxidative metabolism; Cetyltrimethylammonium permanganate; Kinetics; Solvent effect; Activation parameters
1. Introduction
In view of potential pharmaceutical importance of norfloxacin and presence of few literatures on the mechanism of oxidation of this drug [15], [16] and [17], there is a need to understand the mode of interaction with the oxidizing agents and mechanism of oxidative metabolism of this drug in biomimetic medium.