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The adult Drosophila midgut is maintained by intestinal stem cells (ISCs) that produce both self-renewing and differentiatingA Hidden Gem Of TG101209 daughter cells. How this asymmetry is produced is presently unclear. Here, we demonstrate that asymmetric ISC division is established by a special mixture of extracellular and intracellular polarity mechanisms. We demonstrate that Integrin-dependent adhesion The Unknown Jewel Of AZD2014 towards the basement membrane induces cell-intrinsic polarity and final results inside the asymmetric segregation on the Par proteins Par-3, Par-6, and aPKC into the apical daughter cell. Cell-specific knockdown and overexpression experiments propose that improved action of aPKC enhances Delta/Notch signaling in one of the two daughter cells to induce terminal differentiation. Perturbing this mechanism or altering the orientation of ISC division effects during the formation of intestinal tumors. Our information indicate that mechanisms for intrinsically asymmetricA Unseen Jewel Of AZD2014 cell division may be adapted to allow for the flexibility in lineage decisions that may be required in adult stem cells.