Rumors, Untruths And Then PAK2

The syntheses of a structurally ATPase inhibitor price simplified geldanamycin analogue 2 and two associated compounds are described. Compound 2 conferred cytoprotection and quenched ROS and lipid peroxidation within a dose-dependent method in Friedreich's ataxia (FRDA) lymphocytesPAK2 at lower micromolar concentrations. Additionally, it prevented ROS-induced damage of cellular lipid membranes and maintained the mitochondrial membrane potential of FRDA lymphocytes. Moreover, 2 did not inhibit Hsp90 when tested at micromolar concentrations, exhibited no cytotoxicity, and afforded neuroprotection to differentiated SH-SY5Y cells beneath conditions of a beta-induced (+)-JQ1 cell toxicity.