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Frontal plane T-wave axis and QRS-T angle are novel electrocardiographic ventricular CSF-1R repolarization parameters which were scarcely evaluated in form two diabetes. The aim was to investigate the factors associated with these parameters of abnormal ventricular repolarization in the cross-sectional evaluation of 594 sufferers with variety 2 diabetes. Clinical, laboratory, 2D-echocardiographic, ambulatory blood pressure (BP) monitoring, aortic pulse wave velocity (PWV) and carotid ultrasonographic information had been obtained. Digital 12-lead ECG was recorded, and frontal plane T-wave axis and QRS-T angle were instantly measured. T-wave kinase inhibitor Vincristine axis was regarded as abnormal if > 75A degrees or < 15A degrees and QRS-T angle if a parts per thousand yen73A degrees in men and a parts per thousand yen67A degrees in woman.
Associations had been assessed by bivariate tests and multivariate logistic regressions. One hundred and four (20.9 %) patients had abnormal T-wave axis, and 84 (14 %) had increased QRS-T angle. Patients with abnormal ventricular repolarization have been older and had greater prevalence of micro- and macrovascular diabetic complications than individuals with normal repolarization. They had higher office and ambulatory BPs, greater prevalence of the non-dipping pattern, and greater left ventricular mass, aortic PWV and carotid intima-media thickness. On multivariate analysis, abnormal ventricular repolarization parameters had been independently connected to left ventricular hypertrophy, non-dipping pattern, higher ambulatory systolic BPs, glycated hemoglobin and common carotid intima-media thickness, and with the presence of coronary artery disease. In conclusion, abnormal frontal plane T-wave axis and QRS-T angle are independently associated with several markers of pre-clinical atherosclerotic disease; whether these associations represent additional cardiovascular risk in form 2 diabetes shall be confirmed in prospective studies.